Human monoclonal antibodies against cd30

Details Human monoclonal antibodies against cd30 Human monoclonal antibodies against cd30

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2471702

Isolated human monoclonal antibodies which bind to CD30 (e.g., human CD30) are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

L'invention concerne des anticorps monoclonaux humains isolés qui se fixent au CD30 (par exemple le CD30 humain). Les anticorps humains peuvent être produits dans un animal transgénique non humain, par exemple une souris transgénique, susceptible de produire plusieurs isotypes d'anticorps monoclonaux humains en subissant une recombinaison V-D-J et une commutation isotypique. L'invention concerne également des dérivés des anticorps humains (par exemple des anticorps bispécifiques et des immunoconjugués) des compositions pharmaceutiques comprenant les anticorps humains, des animaux transgéniques non humains et des hybridomes qui produisent les anticorps humains, ainsi que des procédés thérapeutiques et diagnostiques relatifs à l'utilisation de ces anticorps humains.

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