Human monoclonal antibodies against interleukin 8 (il-8)

Details Human monoclonal antibodies against interleukin 8 (il-8) Human monoclonal antibodies against interleukin 8 (il-8)

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2510087

Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

L'invention concerne des anticorps monoclonaux humains isolés qui se lient à l'interleukine 8 (IL-8) (par exemple, IL-8 humaine). Lesdits anticorps humains peuvent être produits par un hybridome, un transfectome ou dans un animal transgénique non humain, par exemple une souris transgénique, capable de produire plusieurs isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et par commutation isotypique. L'invention concerne également des compositions pharmaceutiques comprenant lesdits anticorps humains, des animaux transgéniques non humains, des hybridomes et des transfectomes qui produisent ces anticorps humains ainsi que des méthodes thérapeutiques et diagnostiques utilisant les anticorps humains de l'invention.

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