Human monoclonal antibodies against oxidized ldl receptor...

Details Human monoclonal antibodies against oxidized ldl receptor... Human monoclonal antibodies against oxidized ldl receptor...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12P 21/08 (2006.01) C07K 14/705 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2401993

Various human monoclonal antibodies that bind to human LOX-X and inhibit the binding of in-vivo LOX-1 ligands to LOX-1 , and the LOX-1-mediated incorporation of the ligands into cells, were obtained by immunizing human antibody-producing transgenic mice (created by genetic engineering) with soluble human oxidized LDL receptor (LOX-1). Furthermore, the human monoclonal antibodies were found to be effective in preventing and treating a variety of diseases.

L'invention concerne l'obtention de divers anticorps monoclonaux humains, qui se lient au LOX-1 humain et qui inhibent ainsi la liaison du LOX-1 aux ligands in vivo et l'incorporation desdits ligands dans les cellules médiées par LOX-1. A cet effet, on immunise des souris transgéniques produisant des anticorps humains qui ont été obtenues par des techniques de génie génétique faisant intervenir le récepteur (LOX-1) humain des LDL oxydées. Il s'avère que lesdits anticorps monoclonaux sont efficaces pour la prévention et le traitement de diverses maladies.

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