Human monoclonal antibodies capable of oligospecifically...

Details Human monoclonal antibodies capable of oligospecifically... Human monoclonal antibodies capable of oligospecifically...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) C12N 15/85 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2322003

A human monoclonal antibody capable of recognizing major tumor-associated gangliosides was isolated, sequenced and characterized. The human monoclonal antibody and antigen binding fragments therein are useful for detecting tumor associated antigens, diagnosis of cancer cells expressing the antigens, and for therapeutic treatment of cancers.

On a isolé, séquencé et caractérisé un anticorps monoclonal capable de reconnaître les principaux gangliosides associés aux tumeurs. L'anticorps monoclonal humain et les Fab qu'il contient sont utiles pour la détection d'antigènes associés aux tumeurs, pour le diagnostic de cellules cancéreuses exprimant les antigènes et pour le traitement thérapeutique des cancers.

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