C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2192079
The variable chains of two human monoclonal antibodies (HMAbs) of the IgM isotype are characterized by elucidation of cDNAs encoding those chains. The HMAbs are specific against cell cycle independent, glioma-associated antigen, and the antibodies do not recognize cultured normal human astrocytes. Immunoconjugates based on the sequences identified should target both proliferating and non-proliferating glioma cells in vivo, thus providing a valuable adjunctive therapy in the treatment of these tumors.
On a caractérisé les chaînes variables de deux anticorps monoclonaux humains (AnMH) de l'isotype IgM, en déterminant les séquences des ADN complémentaires codant pour ces chaînes. Ces AnMH réagissent spécifiquement avec des antigènes de surface de gliomes, indépendants du cycle cellulaire et ils ne reconnaissent pas les astrocytes humains normaux, obtenus par culture. Les conjugués immunologiques de ces anticorps basés sur les séquences identifiées devraient permettre un ciblage in vivo sur les cellules proliférantes ou non de gliomes et donc un traitement d'appoint de ces tumeurs.
Dan Michael D.
Ridout & Maybee Llp
Viventia Biotech Inc.
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