Human monoclonal antibodies to btla and methods of use

Details Human monoclonal antibodies to btla and methods of use Human monoclonal antibodies to btla and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/46 (2006.01) C12N 5/18 (2006.01) C12N 15/13 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2669921

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to BTLA with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for detecting BTLA, as well as methods for treating various diseases, including cancer and infectious diseases, using anti- BTLA antibodies.

L'invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains qui se lient spécifiquement au BTLA avec une haute affinité. Des molécules d'acide nucléique codant pour les anticorps de la révélation, des vecteurs d'expression, des cellules hôte et des procédés pour exprimer les anticorps de la révélation sont également proposés. Des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de la révélation sont également proposés. La révélation propose également des procédés pour détecter le BTLA, ainsi que des procédés pour traiter diverses maladies, comprenant le cancer et des maladies infectieuses, utilisant des anticorps anti-BTLA.

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