C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2623236
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
La présente invention concerne des anticorps monoclonaux isolés, notamment humains, se liant spécifiquement au CD70 avec une affinité élevée. L'invention concerne également des molécules d'acide nucléique codant ces anticorps, des vecteurs d'expression, des cellules hôtes, et des procédés permettant l'expression des anticorps de l'invention. L'invention concerne aussi des immunoconjugués, des molécules bispécifiques, et des compositions pharmaceutiques comprenant ces anticorps. L'invention concerne enfin des traitements anticancéreux, des traitements de maladies auto-immunes, des inflammation et des infections virales.
Cardarelli Josephine M.
Coccia Marco A.
Huang Haichun
King David John
Lu Li-Sheng
Medarex Inc.
Smart & Biggar
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