Human monoclonal antibodies to ctla-4

Details Human monoclonal antibodies to ctla-4 Human monoclonal antibodies to ctla-4

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C12N 5/078 (2010.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2619682

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. Also provided is a cell culture system for assaying T cell stimulation.

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