Human monoclonal antibodies to ctla-4

Details Human monoclonal antibodies to ctla-4 Human monoclonal antibodies to ctla-4

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01H 5/00 (2006.01) A01K 67/00 (2006.01) A61K 35/12 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2356215

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. Also provided is a cell culture system for assaying T cell stimulation.

La présente invention concerne des anticorps monoclonaux entièrement humains dirigés contre l'antigène CTLA-4. L'invention concerne également des séquences nucléotidiques codant des molécules d'immunoglobuline à chaînes lourdes et légères, des séquences d'acides aminés contenant des molécules d'immunoglobuline à chaînes lourdes et légères et notamment des séquences de chaînes lourdes et légères contiguës, couvrant les régions déterminant la complémentarité (CDR), spécifiquement depuis l'intérieur de FR1 et/ou CDR1 jusqu'à CDR3 et/ou l'intérieur de FR4. En outre, l'invention concerne des anticorps présentant des propriétés de liaison similaires et des anticorps (ou autres antagonistes) ayant une fonctionnalité similaire en tant qu'anticorps.

Affiliated with

Also associated with

Rating

Human monoclonal antibodies to ctla-4 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human monoclonal antibodies to ctla-4, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monoclonal antibodies to ctla-4 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1465663