C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/45, 195/1.11
C12N 5/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12P 21/00 (2006.01) G01N 33/577 (2006.01)
Patent
CA 1269337
Abstract Human monoclonal antibodies (HmAbs) capable of reacting with cytokeratin are disclosed. It has been found that HmAbs De8, M54, M307, Hull, C29, Hu22 and Pa24 may be used to detect these cytoskeletal proteins in various cells. By means of these HmAbs the embryological origin of cells may be determined. This information may be used to determine the possible tissue source of metastasized tumor. and greatly affects the management of these cancers.
482988
Cote Richard J.
Houghton Alan N.
Oettgen Herbert F.
Old Lloyd J.
Thomson Timothy M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sloan Kettering Institute For Cancer Research
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