Human monoclonal antibodies to dendritic cells

Details Human monoclonal antibodies to dendritic cells Human monoclonal antibodies to dendritic cells

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2466049

Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

L'invention concerne des anticorps monoclonaux humains isolés et des fragments de liaison à l'antigène de ces anticorps, qui se lient spécifiquement avec les cellules dendritiques. L'invention concerne également des molécules bispécifiques, des immunotoxines et des conjugués antigéniques qui comprennent des anticorps ou des fragments d'anticorps. Ces anticorps humains peuvent être produits dans des animaux transgéniques, p. ex. dans une souris transgénique qui est capable de produire de multiples isotypes d'anticorps monoclonaux humains après avoir subi une recombinaison V-D-J et une commutation isotypique. L'invention concerne également des compositions pharmaceutiques comprenant des anticorps humains, des animaux transgéniques, et des hybridomes qui produisent les anticorps humains, ainsi que des méthodes thérapeutiques et diagnostiques comprenant l'utilisation de ces anticorps humains.

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