Human monoclonal antibodies to dendritic cells

Details Human monoclonal antibodies to dendritic cells Human monoclonal antibodies to dendritic cells

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A01K 67/027 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/46 (2006.01) C12N 5/20 (2006.01) C12N 15/63 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2408594

Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal,e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

L'invention se rapporte à des anticorps monoclonaux humains isolés et à des parties de ceux-ci se liant à des antigènes, qui se lient de manière spécifique aux cellules dendritiques. L'invention se rapporte également à des molécules bispécifiques, à des immunotoxines et à des conjugués d'antigènes qui incluent ces anticorps ou parties d'anticorps. Ces anticorps humains peuvent produire dans un animal transgénique non humain, par exemple une souris transgénique, de multiples isotypes d'anticorps monoclonaux humains, du fait qu'ils subissent une recombinaison V-D-J et une commutation d'isotypes. L'invention se rapporte aussi à des compositions pharmaceutiques comportant ces anticorps humains, à des animaux transgéniques non humains et à des hybridomes qui produisent lesdits anticorps humains, ainsi qu'à des procédés thérapeutiques et diagnostiques permettant d'utiliser ces anticorps humains.

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