C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12N 5/20 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2450285
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transgenic mouse, capable of producing multiple isotypes of human nonoclonal antibodies by undergoing V-D-J recombination and isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
L'invention concerne des anticorps monoclonaux humains isolés qui se lient spécifiquement à l'EGFR, des molécules et des compositions associées à base d'anticorps. Les anticorps humains peuvent être produits par une souris transgénique, capable de produire des isotypes multiples d'anticorps monoclonaux humains par mise en oeuvre d'une recombinaison V-D-J et par commutation isotypique. L'invention concerne aussi des compositions pharmaceutiques comprenant les anticorps humains, des hybridomes et des animaux transgéniques non humains produisant les anticorps humains, ainsi que des procédés de diagnostic et de thérapie utilisant les anticorps humains.
Gerritsen Arnout F.
Halk Edward
Van de Winkel Jan
Van Dijk Marcus A.
Borden Ladner Gervais Llp
Genmab A/s
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