Human monoclonal antibodies to fc alpha receptor (cd89)

Details Human monoclonal antibodies to fc alpha receptor (cd89) Human monoclonal antibodies to fc alpha receptor (cd89)

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12N 15/79 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2437814

Human monoclonal antibodies which bind specifically to Fc alpha receptor (CD89), including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human effector cells (e.g.macrophages) against a target cell (e.g. a cancer cell, an infectious agent, etc.). for this purpose, bifunctional antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc-alpha receptor antibody and the binding region of a target-specific antibody. Targeted effector cells can specifically lyse target cells.

L'invention concerne des anticorps monoclonaux humains qui se lient spécifiquement à un alphabloquant Fc (CD89), comprenant des anticorps monoclonaux qui réagissent spécifiquement au récepteur Fc pour un IgA des cellules effectrices humaines. Les agents de liaison, par exemple., les anticorps servent à cibler les cellules effectrices humaines (par exemplemacrophages) contre une cellule cible (par exemple une cellule cancéreuse, un agent infectieux, etc.) dans ce but, des anticorps bifonctionnels ou des hétéroanticorps peuvent être construits en contenant la région de liaison dérivée d'un anticorps d'alphabloquant anti-Fc et la région de liaison d'un anticorps de cible spécifique. Les cellules effectrices ciblées peuvent lyser spécifiquement les cellules cibles.

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