C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2568661
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to CD64 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating autoimmune disorders, transplant rejection, Graft Versus Host Disease, or cancer and for enhanced presentation of antigen using conjugates of an antigen and an anti-CD64 antibody.
L'invention porte: sur des anticorps monoclonaux en particulier humains se fixant au CD64 avec une grande affinité; sur des molécules d'acides nucléiques codant pour lesdits anticorps; sur des vecteurs d'expression, des cellules hôtes et les procédés d'expression desdits anticorps; sur des immunoconjugués, des molécules bispécifiques et des préparations pharmaceutiques comprenant lesdits anticorps; sur des méthodes de traitement de maladies auto-immunes, de rejet des transplants, de la réaction du greffon contre l'hôte, ou du cancer; et sur la présentation améliorée d'antigènes utilisant des conjugués d'antigène et d'anticorps anti-CD64.
Graziano Robert
Sundarapandiyan Karuna
Medarex Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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