Human monoclonal antibodies to hiv-1 mn gp 120

Details Human monoclonal antibodies to hiv-1 mn gp 120 Human monoclonal antibodies to hiv-1 mn gp 120

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/42 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C12N 15/49 (2006.01) C12N 15/863 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2058630

2058630 9015078 PCTABS00002 An antibody capable of neutralizing the MN prototype of HIV or an MN variant virus thereof, wherein an amino acid sequence within the principal neutralizing domain of the MN prototype comprises the sub-sequence, at positions A1-A17 of the principal neutralizing domain, of amino acid residues K-R-K-R-I-H-I-G-P-G-R-A-F-Y-T-T-K, and the corresponding amino acid sub-sequence of the MN variant includes a completely homologous sequence at the I-G-P-G-R residues at positions A7-A11 and at least 36 % homology over the remaining residues of the MN prototype sub-sequence.

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