C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2479927
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to interleukin 5 (IL-5), which is preferably human IL-5. The invention also relates to human anti-IL-5 antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IL-5 antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IL-5 antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IL-5 antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
L'invention concerne des anticorps ainsi que les parties de liaison à l'antigène de ces anticorps qui se lient spécifiquement à l'interleukine 5 (IL-5), de préférence à l'interleukine humaine IL-5. L'invention concerne en outre des anticorps humains anti-IL-5, qui comprennent des anticorps chimères, bispécifiques, dérivés, des anticorps à chaîne unique ou des parties de protéines de fusion. Par ailleurs, l'invention concerne des molécules d'immunoglobuline à chaînes lourdes et légères isolées dérivées des anticorps anti-IL-5, ainsi que des molécules d'acides nucléiques qui codent ces molécules. L'invention concerne également des procédés de préparation de ces anticorps anti-IL-5, des compositions pharmaceutiques contenant ces anticorps ainsi que des méthodes d'utilisation de ces anticorps et de leurs compositions à des fins diagnostiques et thérapeutiques. De plus, l'invention concerne des méthodes de thérapie génique qui font intervenir des molécules d'acides nucléiques codant les molécules d'immunoglobuline à chaînes lourdes et/ou légères contenant les anticorps humains anti-IL-5. L'invention concerne enfin des méthodes de thérapie génique ainsi que des animaux transgéniques qui contiennent les molécules d'acides nucléiques de l'invention.
Corvalan Jose
Greenfeder Scott
Abgenix Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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