Human monoclonal antibodies to o8e

Details Human monoclonal antibodies to o8e Human monoclonal antibodies to o8e

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2630483

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

L'invention porte: sur des anticorps monoclonaux isolés et en particulier sur des anticorps monoclonaux humains se fixant spécifiquement à l'O8 avec une grande affinité; sur des molécules d'acides nucléiques codant pour lesdits anticorps; sur des vecteurs d'expression; sur des cellules hôtes; sur des méthodes d'expression desdits anticorps, ainsi que: sur des immunoconjugués, sur des molécules bispécifiques, sur des préparations pharmaceutiques contenant lesdits anticorps; et sur des méthodes de traitement du cancer.

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