C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/18 (2006.01) C12N 15/63 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2612241
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-Ll with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-Ll, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-Ll antibodies.
La présente invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains qui se lient spécifiquement à PD-L1 avec une affinité élevée. L'invention concerne également des molécules d'acides nucléiques codant pour les anticorps de l'invention, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps de l'invention. L'invention concerne en outre des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention. L'invention concerne enfin des méthodes de détection de PD-L1, ainsi que des méthodes de traitement de diverses maladies, notamment du cancer et de maladies infectieuses, à l'aide d'anticorps anti-PD-L1.
Chen Haibin
Huang Haichun
Korman Alan J.
Passmore David B.
Selby Mark J.
Medarex Inc.
Smart & Biggar
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