C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2474616
Isolated human monoclonal antibodies which bind to PSMA, and related antibody- based compositions and molecules, are disclosed. The human antibodies can be produced in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
L'invention concerne des anticorps monoclonaux humains isolés qui se lient à l'antigène d'enveloppe prostatique spécifique (PSMA), des compositions contenant des anticorps associés et des molécules. On peut produire ces anticorps humains dans un animal transgénique non humain, par exemple, une souris transgénique, capable de produire de multiple isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et commutation isotypique. L'invention concerne également des compositions pharmaceutiques comprenant lesdits anticorps humains, des animaux transgéniques non humains et des hybridomes produisant ces anticorps humains ainsi que des méthodes thérapeutiques et diagnostiques utilisant lesdits anticorps humains.
Black Amelia
Deo Yashwant M.
Graziano Robert
Holmes Eric H.
Hudson Debra
Borden Ladner Gervais Llp
Medarex Inc.
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