C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2632552
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
La présente invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains, qui se lient spécifiquement à PTK7 avec une affinité élevée. La présente invention concerne également des molécules d'acide nucléique codant pour les anticorps de l'invention, des vecteurs d'expression, des cellules hôtes et des procédés pour exprimer les anticorps de l'invention. La présente invention concerne aussi des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention. L'invention concerne en outre des procédés pour détecter PTK7, ainsi que des procédés pour traiter différentes maladies, comprenant le cancer et des maladies infectieuses, en utilisant des anticorps anti-PTK7.
Lu Li-Sheng
Pan Chin
Terrett Jonathan Alexander
Borden Ladner Gervais Llp
Medarex Inc.
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