Human monoclonal antibody against a costimulatory signal...

Details Human monoclonal antibody against a costimulatory signal... Human monoclonal antibody against a costimulatory signal...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/554 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2344086

Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

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