C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/28 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) G01N 33/576 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2227548
Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are activated in vitro with pokeweed mitogen and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.
Lignée cellulaire d'hybridomes produisant des anticorps humains aptes à se lier à l'antigène de surface du virus de l'hépatite B (HBVsAg), et anticorps produits par cette lignée cellulaire. On a également prévu différentes applications de ces anticorps à la prévention et au traitement de l'infection par le VHB. On active in vitro, à l'aide de mitogènes de phytolaque, les lymphocytes circulant dans le sang périphérique de donneurs humains présentant un titre élevé d'anticorps anti-HBVsAg, puis on provoque leur fusion avec des cellules hétéromyélomateuses afin de créer des hybridomes sécrétant des anticorps humains présentant une affinité et une spécificité élevées vis-à-vis du HBVsAg.
Smart & Biggar
Xtl Biopharmaceuticals Limited
Yeda Research And Development Company Ltd.
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