C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 1/16 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01)
Patent
CA 2389862
Various human monoclonal antibodies which bind to human TGF-.beta.II receptor and thus inhibit the signal transduction of human TGF-.beta. into cells are obtained by immunizing human antibody-producing transgenic mice constructed by using genetic engineering techniques with the human TGF-.beta.II receptor. Further, it is found out that these human monoclonal antibodies are efficacious in preventing and treating various diseases induced by human TGF- .beta. in various organs (for example, tissue fibrosis).
Cette invention concerne divers anticorps monoclonaux humains qui se lient au récepteur TGF-.beta.II humain et donc inhibent la transduction du signal du TGF-.beta. humain dans des les cellules. Ces anticorps s'obtiennent en immunisant au moyen du récepteur humain TGF-.beta.II des souris transgéniques qui produisent des anticorps humain et qui sont obtenues par des techniques de génie génétique. On a constaté en outre que ces anticorps monoclonaux humains permettaient de prévenir et de traiter efficacement diverses maladies induites par le TGF-.beta. dans divers organes (telles que la fibrose tissulaire).
Kamada Masafumi
Sakamoto Shinji
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Japan Tobacco Inc.
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