C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0735 (2010.01) C12N 5/073 (2010.01) A61K 35/48 (2006.01) A61K 39/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2404634
This invention discloses a substantially pure population of human M~llerian duct-derived epithelial cells and methods of isolating and culturing the M~llerian duct-derived epithelial cells. By carefully manipulating the microenvironment in which the M~llerian duct-derived epithelial cells are grown, multiple passages are attainable wherein the M~llerian duct-derived epithelial cells are capable of becoming uterine, cervical, vaginal, and oviductal cells. In addition, several uses of human M~llerian duct-derived epithelial cells and cells differentiating therefrom are disclosed herein.
L'invention concerne une population sensiblement pure de cellules ~pith~liales d~riv~es du canal de M¾ller, ainsi que des m~thodes d'isolation et de culture de cellules ~pith~liales d~riv~es du canal de M¾ller. En manipulant pr~cautionneusement le micro-environnement dans lequel ces cellules ~pith~liales d~riv~es du canal de M¾ller sont cultiv~es, on rend plusieurs passages accessibles, lesdites cellules ~pith~liales d~riv~es du canal de M¾ller pouvant devenir des cellules oviductales, vaginales, cervicales et ut~rines. Par ailleurs, l'invention concerne plusieurs m~thodes visant ~ utiliser des cellules ~pith~liales d~riv~es du canal de M¾ller humain ainsi que des cellules s'en diff~renciant.
Li Ronghao
Mather Jennie Powell
Borden Ladner Gervais Llp
Raven Biotechnologies Inc.
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