Human netrin-1

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250263

Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.

Protéines spécifiques de la classe des netrines, acides nucléiques codant ces netrines, réactifs d'hybridation, sondes et amorces capables d'effectuer une hybridation avec des gènes de netrine et procédés de recherche par criblage de banques chimiques de composés de départ pour des agents pharmacologiques utiles dans le diagnostic ou le traitement de la croissance cellulaire indésirable associée à une maladie. Un procédé de recherche consiste à créer un mélange composé d'une netrine de recombinaison, d'une cible de fixation naturelle intracellulaire de ladite protéine et d'un agent pharmacologique candidat, à effectuer l'incubation du mélange dans des conditions où ladite protéine se fixe sélectivement à ladite cible de fixation, sauf si ledit agent pharmacologique candidat est présent et à détecter la présence ou l'absence de fixation spécifique de ladite netrine à ladite cible de fixation.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Human netrin-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human netrin-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human netrin-1 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1904962

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.