Human neurokinin-1 receptor

Details Human neurokinin-1 receptor Human neurokinin-1 receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2066491

Recombinant human neurokinin-1 receptor (human NK1R) is disclosed which has been prepared by polymerase chain reaction techniques. Also disclosed is the complete sequence of human NK1R complementary DNA; expression systems, including a CH0 (chinese hamster ovarian cell line) stable expression system; and an assay using the CH0 expression system. NK1R, also known as substance P receptor, can be used in an assay to identify and evaluate entities that bind substance P receptor. The assay can also be used in conjunction with diagnosis and therapy to determine the body fluid concentration of substance P in arthritis patients.

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