Human neurokinin-1 receptor short form

Details Human neurokinin-1 receptor short form Human neurokinin-1 receptor short form

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2068372

0967s/6547A 18407 TITLE OF THE INVENTION NOVEL HUMAN NEUROKININ-1 RECEPTOR SHORT FORM ABSTRACT OF THE INVENTION A novel recombinant human neurokinin-1 receptor short form (hereinafter identified as human MKlR sF) is disclosed which has been prepared by polymerase chain reaction techniques. Also disclosed is the complete sequence of human NKlR sF complementary DNA; expression systems, including a CHO (chinese hamster ovarian cell line) stable expression system; and an assay using the CHO expression system. NKlR sF, can be used in an assay to identify and evaluate entities that bind substance P receptor or NKlR sF. The assay can also be used in conjunction with diagnosis and therapy to determine the body fluid concentration of substance P antagonists in arthritis patients.

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