Human neuronal nicotinic acetylcholine receptor compositions...

Details Human neuronal nicotinic acetylcholine receptor compositions... Human neuronal nicotinic acetylcholine receptor compositions...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2155330

Nucleic acids encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said nucleic acids, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha.4 and .alpha.7) and beta subunits (specifically (.beta.4) are provided. In addition, combinations of subunits (i.e., .alpha.1, .alpha.2, .alpha.3, .alpha.4, and/or .alpha.7 subunits in combination with .beta.4 subunits; or (.beta.2, .beta.3 and/or .beta.4 subunits in combination with .alpha.4 and/or .alpha.7 subunits) are provided.

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