C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2295303
The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.
La présente invention concerne un nouveau membre de la famille NK des gènes à séquence homéotique. En particulier, l'invention concerne des molécules d'acide nucléique isolées codant pour la protéine du gène 1 spécifique de la prostate NK-3 humain (NKX3.1). L'invention concerne également les polypeptides NKX3.1, ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison pour les produire. L'invention concerne, en outre, des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité du NKX3.1. Par ailleurs, l'invention concerne des méthodes diagnostiques de détection du cancer de la prostate et d'autres cancers, ainsi que des méthodes thérapeutiques destinées au cancer de la prostate et à d'autres cancers.
Carter Kenneth C.
He Wei-Wu
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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