Human orphan receptor ntr-1

Details Human orphan receptor ntr-1 Human orphan receptor ntr-1

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2299619

The present invention provides for a nucleic acid sequence, designated as HUMAN NTR-1, that encodes a novel orphan receptor expressed in pancreas and fetal heart. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the HUMAN NTR-1 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between NTR-1 and agents that initiate signal transduction through binding to NTR-1.

L'invention porte sur une séquence d'acide nucléique dite HUMAN NTR-1 codant pour un nouveau récepteur orphelin exprimé dans le pancréas et le coeur du foetus. L'invention porte également sur des systèmes d'essai pouvant servir à détecter ou mesurer les ligands se fixant au produit génique HUMAN NTR-1; elle porte en outre sur des procédés thérapeutiques basés sur l'interaction entre le NTR-1 et des agents provoquant la transduction de signaux en se fixant au NTR-1.

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