Human orthologues of wart

Details Human orthologues of wart Human orthologues of wart

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 39/00 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 5/20 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2318403

The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that modulate the function of an hWART polypeptide. Also disclosed are methods for diagnosing abnormal cell proliferative conditions in an organism using hWART-related molecules or compounds.

Cette invention porte en partie sur des molécules d'acides nucléiques et en partie sur des molécules d'acides nucléiques codant des segments de protéines entières hWART, des vecteurs d'acides nucléiques contenant des molécules d'acides nucléiques hWART, des cellules de recombinaison contenant ces mêmes vecteurs, des polypeptides purifiés à partir de ces cellules de recombinaison, des anticorps dirigés contre ces polypeptides et sur des procédés d'identification de composés qui modulent fonctionnement du polypeptide hWART. ON décrit également des procédés qui permettent de diagnostiquer des conditions de prolifération cellulaire anormale dans un organisme à l'aide de composés ou de molécules du type hWART.

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