Human osteoclast-derived cathepsin

Details Human osteoclast-derived cathepsin Human osteoclast-derived cathepsin

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) A61P 19/08 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/48 (2006.01) C12N 15/11 (2006.01) C12N 15/66 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01) C12Q 1/37 (2006.01) G01N 33/535 (2006.01)

Patent

CA 2380690

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA (RNA) coding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

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