C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2443236
Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA (RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
Adams Mark D.
Blake Judith A.
Drake Fred H.
Fitzgerald Lisa M.
Fraser Claire M.
Human Genome Sciences Inc.
Mbm & Co.
Smithkline Beecham Corporation
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