Human osteoclast-derived cathepsin

Details Human osteoclast-derived cathepsin Human osteoclast-derived cathepsin

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184908

Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA (RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

L'invention concerne un polypeptide de cathépsine humaine dérivée d'ostéoclastes (cathépsine 0), et un ADN (ARN) codant pour ces polypeptides de cathépsine 0. L'invention concerne également un mode opératoire de production desdits polypeptides par des techniques de recombinaison. L'invention porte, par ailleurs, sur des anticorps, des antagonistes et des inhibiteurs dudit polypeptide qui peuvent être utilisés pour prévenir l'action de ce dernier et, à des fins thérapeutiques, pour traiter les maladies osseuses telles que l'ostéoporose, et les cancers à métastases tumorales.

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