Human ovarian mesothelial cells and methods of isolation and...

Details Human ovarian mesothelial cells and methods of isolation and... Human ovarian mesothelial cells and methods of isolation and...

C - Chemistry, Metallurgy

12

N

C12N 5/073 (2010.01) A61K 35/54 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2404265

The invention discloses a substantially pure population of human ovarian mesothelial cells and methods of isolating and culturing the ovarian mesothelial cells. By carefully manipulating the microenvironment of the ovarian mesothelial cells, multiple passages are attainable wherein the ovarian mesothelial cells are capable of becoming ovary surface epithelial cells or granulosa cells. In addition, several methods of use of human ovarian mesothelial cells are disclosed herein.

L'invention concerne une population sensiblement pure de cellules mésothéliales ovariennes humaines, ainsi que des procédés d'isolement et de culture de ces cellules. En manipulant soigneusement le microenvironnement des cellules mésothéliales ovariennes, il est possible de trouver les mécanismes permettant à ces cellules de devenir des cellules épithéliales de surface d'ovaire ou des cellules de membrane granuleuse. En outre, l'invention concerne plusieurs procédés d'utilisation de cellules mésothéliales ovariennes humaines.

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