C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 15/10 (2006.01) C12N 15/81 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2380631
The present invention provides isolated polypeptides of human p53 that contain mutations. These mutations can be toxic mutations, supertransactivating mutations or tox-suppressor mutations. Further provided by the invention are methods of identifying toxic, supertransactivating, weak transactivating and tox-suppressor mutations as well as methods of identifying compounds that mimic the toxic, supertransactivating and tox-suppressor mutations in human p53. Also provided are methods of inducing toxicity in a cell by administering a polypeptide comprising a supertransactivating or a toxic mutation.
La présente invention concerne des polypeptides isolés du gène p53 humain renfermant des mutations. Ces mutations peuvent être des mutations toxiques, des mutations supertransactivatrices ou des mutations de suppression du phénotype toxique. L'invention concerne également des méthodes d'identification de ces mutations toxiques, supertransactivatrices, faiblement transactivatrices et de suppression du phénotype toxique, ainsi que des méthodes d'identification de composés imitant les mutations toxiques, supertransactivatrices et de suppression du phénotype toxique du gène p53 humain. L'invention concerne enfin des méthodes permettant d'induire une toxicité dans une cellule par administration d'un polypeptide comprenant une mutation supertransactivatrice ou toxique.
Inga Alberto
Resnick Michael A.
Gowling Lafleur Henderson Llp
The Government Of The United States Of America As Represented By
LandOfFree
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