Human papilloma virus inhibition by a hairpin ribozyme

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 9/127 (2006.01) A61K 31/7105 (2006.01) A61K 33/24 (2006.01) A61K 35/12 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C12N 9/22 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2578402

Synthetic ribozymes, i.e. ribozymes including a hairpin portion, binding sites for binding to a human papilloma virus (HPV) after viral base 419 or 434, respectively, and cleavage sites for cleaving HPV virus are disclosed. The invention also includes a diagnostic assay for determining the presence of HPV-16 in tissues based on PCR amplification.

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