Human papilloma virus inhibition by anti-sense oligonucleotides

Details Human papilloma virus inhibition by anti-sense oligonucleotides Human papilloma virus inhibition by anti-sense oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/025 (2006.01) C12N 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2302148

Antisense oligonucleotides and analogs thereof having phosphorothioate backbone structure and sequences complementary to nucleotides contained with residues 415 to 445 of human papilloma virus 16 (HPV-16). These antisense oligonucleotides and oligonucleotide analogs are used to inhibit HPV-16 expression and to inhibit the growth of cervical tumors.

Cette invention a trait à des oligonucléotides anti-sens et à leurs analogues possédant une structure de squelette phosphorothioate et à des séquences complémentaires des nucléotides que contiennent les restes 415 à 445 du papillomavirus humain 16 (VPH-16). On utilise ces oligonucléotides anti-sens et leurs analogues pour inhiber l'expression de VPH-16 ainsi que pour entraver la croissance de tumeurs cervicales.

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