Human papillomavirus / li-key hybrids and methods of use

Details Human papillomavirus / li-key hybrids and methods of use Human papillomavirus / li-key hybrids and methods of use

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/12 (2006.01) A61P 31/20 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2731444

The present invention is directed towards compositions comprising li-Key / HPV hybrid peptides. The hybrid peptides of the present invention are effective in the generation of CD4+ helper T cell immune responses directed towards the specific HPV epitopes encoded in the hybrid peptide. The inclusion of the li-key peptide in the hybrid causes the peptide to have greater immunogenicity as compared to control peptide. The inclusion of li-Key / HPV hybrid in a peptide vaccine formulation composing both HPV hybrid and HPV CTL epitope peptide (administered concurrently or sequentially) leads to a greater CTL activity against HPV CTL epitopes. The hybrid peptides of the present invention may be useful, for example, for the immunization of subjects against HPV.

Linvention concerne des compositions comprenant des peptides hybrides li-Key/HPV. Les peptides hybrides de linvention sont efficaces pour générer des réponses immunitaires des lymphocytes T auxiliaires CD4+ dirigées vers les épitopes spécifiques HPV codés dans le peptide hybride. Linclusion du peptide li-Key dans lhybride entraîne une plus grande immunogénécité du peptide par rapport à un peptide témoin. Linclusion dun hybride li-Key/HPV dans une formulation de vaccin peptidique composant à la fois un  hybride HPV et un peptide dépitope HPV CTL (administrés simultanément ou séquentiellement) conduit à une activité CTL plus grande à lencontre des épitopes HPV CTL. Les peptides hybrides de linvention peuvent être utilisés, par exemple pour immuniser des sujets contre HPV.

Affiliated with

Also associated with

Rating

Human papillomavirus / li-key hybrids and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human papillomavirus / li-key hybrids and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human papillomavirus / li-key hybrids and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1560763