Human papillomavirus polypeptides and immunogenic compositions

Details Human papillomavirus polypeptides and immunogenic compositions Human papillomavirus polypeptides and immunogenic compositions

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2499837

The present invention provides immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers and in particular, cervical cancer. In particular, this invention relates to fusion proteins, and the nucleic acids encoding these fusion proteins, used to generate immune responses against HPV. Specifically, this invention provides for fusions of HPV E6 and E7 in which the E6 and/or E7 contains one or more mutations. These mutations abrogate the transformation activity of these oncogenic proteins and, thus, confer safety to the E6/E7 fusions. In addition, these fusions maintain or increase the immunogenic efficacy of E6 and E7. Any gene or protein delivery method can be used to deliver or package the immunogenic compositions of the present invention.

L'invention concerne des compositions immunogènes et pharmaceutiques utilisées pour traiter et prévenir des cancers associés au papillomavirus humain (HPV) et en particulier le cancer du col de l'utérus. Cette invention se rapporte en particulier à des protéines de fusion employées pour générer des réponses immunitaires dirigées contre le HPV, ainsi qu'aux acides nucléiques codant ces protéines de fusion. La présente invention concerne de manière spécifique la fusion des protéines E6 et E7 du HPV, E6 et/ou E7 comportant une ou plusieurs mutations. Ces mutations suppriment l'activité transformationnelle des protéines oncogènes et ainsi rendent les fusions E6/E7 inoffensives. En outre, ces fusions permettent de conserver et d'accroître l'efficacité immunogène de E6 et E7. Un quelconque procédé d'administration génique ou protéique peut être employé pour administrer ou conditionner lesdites compositions immunogènes.

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