Human parathyroid hormone muteins and production thereof

Details Human parathyroid hormone muteins and production thereof Human parathyroid hormone muteins and production thereof

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/635 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2075408

- ? - TITLE: HUMAN PARATHYROID HORMONE MUTEINS AND PRODUCTION THEREOF ABSTRACT Disclosed are (1) a human parathyroid hormone mutein which comprises at least one modification selected from the group consisting of (i) deletion of 3 to 6 amino acid residues on the N-terminal side in the amino acid sequence of human parathyroid hormones, (ii) substitution of another lipophilic amino acid residue for at least one methionine residue in said amino acid sequence, and (iii) substitution of a cysteine residue for one amino acid residue within the region of amino acid residue Nos. 34 to 47 in said amino acid sequence; (2) a recombinant DNA having a nucleotide sequence coding for the human parathyroid hormone mutein described in (1); (3) a vector containing the recombinant DNA described in (2); (4) a vector in which the recombinant DNA described in (2) is inserted into a region controlled by an E. coli T7 promoter; (5) a transformant which is transformed by the recombinant DNA described in (2); and a process for producing a human parathyroid hormone mutein which comprises cultivating the transformant described in (5) in a culture medium.

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