Human phosphodiesterase type ivc, and its production and use

Details Human phosphodiesterase type ivc, and its production and use Human phosphodiesterase type ivc, and its production and use

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 31/40 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2182946

Recombinant human phosphodiesterase type IVC is described, and DNA coding for it. Particular conformers of the enzyme are identified, including an R- and S-rolipram stereoselective conformer which is obtainable by expression of human phosphodiesterase type IVC DNA in mammalian or insect cells. The recombinant enzyme may be used in a screen to select a compound capable of modulating the action of the enzyme, or as an immunogen to generate an antibody.

L'invention concerne un IVC du type phosphodiestérase humaine de recombinaison et l'ADN codant pour celui-ci. On a identifié des conformères particuliers de l'enzyme, en particulier un conformère stéréosélectif vis-à-vis du R- et du S-rolipram, que l'on peut obtenir par l'expression de l'ADN codant pour l'IVC du type phosphodiestérase humaine dans des cellules de mammifères ou d'insectes. L'enzyme de recombinaison peut être utilisée dans un dosage sélection pour sélectionner un composé capable de moduler l'action de l'enzyme, ou comme immunogène pour générer un anticorps.

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