Human plasminogen activator

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/72 (2006.01) A61K 38/08 (2006.01) A61K 38/48 (2006.01) C07K 7/06 (2006.01) C12N 9/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2353699

Proteins involved in plasminogen complexation or activation are provided. Portions include a six amino acid peptide which can be used as a plasminogen activator. The peptide is particularly useful when inserted into a plasminogen or plasmin sequence, especially when inserted between the amino acid residues corresponding to amino acid residues 644 and 645 of full length human plasminogen.

Cette invention concerne des protéines qui jouent un rôle dans la formation de complexes ou l'activation de plasminogène. Des parties comprennent un peptide à six acides aminés qui peut être utilisé en qualité d'activateur de plasminogène. Ce peptide est particulièrement utile lorsqu'il est inséré dans un plasminogène ou une séquence de plasmine, notamment lorsqu'il est inséré entre les résidus d'acide aminé correspondant aux résidus d'acide aminé 644 et 645 d'un plasminogène humain dans toute sa longueur.

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