Human platelet-derived growth factor receptor

Details Human platelet-derived growth factor receptor Human platelet-derived growth factor receptor

C - Chemistry, Metallurgy

12

N

530/13, 195/1.2,

C12N 15/18 (2006.01) C07H 21/04 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1339356

A DNA sequence encoding the human platelet-derived growth factor receptor (hPDGF-R) has now been isolated and sequenced. An expression construct comprising the sequence encodes a receptor that can be secreted or incoporated into the membrane of a mammalian cell. The incorporated receptor is functionally equivalent to the wild-type receptor, conferring a PDGF-sensitive mitogenic response on cells lacking the receptor. The construct can be used for enhancing PDGF response of cells, determining the regions involved in transducing the signal in response to PDGF binding, providing mutated analogs and evaluating drugs for their physiologic activity.

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