Human poly(adp-ribose) polymerase 2 materials and methods

Details Human poly(adp-ribose) polymerase 2 materials and methods Human poly(adp-ribose) polymerase 2 materials and methods

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376717

The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the hPARP2 polypeptides, antibodies that are immunoreactive with the hPARP2 polypeptides. In addition, there are provided methods for identifying specific binding partners of hPARP2, and more particularly methods for identifying binding partners that modulate biological activity of hPARP2. Methods of modulating biological activity of hPARP2 in vitro andin vivo are also provided.

L'invention concerne de nouveaux polypeptides poly(ADP-ribose) polymerase (hPARP2) humains, des polynucléotides qui codent ces polypeptides, des produits de recombinaison d'expression incluant ces mêmes polynucléotides ainsi que des cellules hôtes transformées par les produits de recombinaison d'expression. L'invention concerne également des procédés de production des polypeptides hPARP2, anticorps immunoréactifs vis-à-vis des polypeptides hPARP2. De plus, l'invention procure des procédés d'identification des partenaires de liaison spécifiques des hPARP2, et tout particulièrement, des procédés d'identification des partenaires de liaison qui modulent l'activité biologique des hPARP2. L'invention fournit encore des procédés de modulation de l'activité biologique des hPARP2 in vitro et in vivo.

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