C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2408360
The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.
La présente invention concerne des compositions polypeptidiques qui se lient aux épitopes de surface cellulaire et, dans le cas de formes multivalentes, provoquent la mort des cellules, notamment des cellules tumorales lymphoïdes. Dans le cas de formes monovalentes, ces compositions polypeptidiques entraînent l'immunosuppression ou inhibent l'activation des lymphocytes. Par ailleurs, cette invention concerne des acides nucléiques codant ces polypeptides, des méthodes de production de ces polypeptides, des méthodes de destruction de cellules, des méthodes d'immunosuppression d'un patient, des compositions pharmaceutiques, diagnostiques et multivalentes, des kits contenant lesdits polypeptides ainsi que les utilisations de ces polypeptides.
Brunner Christoph
Nagy Zoltan
Rauchenberger Robert
Tesar Michael
Thomassen-Wolf Elisabeth
Borden Ladner Gervais Llp
Gpc Biotech Ag
Morphosys Ag
Rauchenberger Robert
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