Human proinsulin and preproinsulin genes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

195/1.14, 195/1.

C12N 1/20 (2006.01) C07K 14/62 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1180289

Abstract of the Disclosure A DNA having a base sequence coding for human proinsulin and a DNA having a base sequence coding for human pre-proinsulin have been cloned, and novel recombinant DNA transfer vectors containing said cloned DNAs have been constructed. Novel microorganisms transformed by said recombinant transfer vectors have been obtained. Certain or said transformed microorganisms have demonstrated capability, to express,the cloned DNAs, synthesizing a protein comprising human proinsulin and a protein comprising human pre-proinsulin.

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