Human proinsulin c-peptide derivatives

Details Human proinsulin c-peptide derivatives Human proinsulin c-peptide derivatives

C - Chemistry, Metallurgy

07

K

530/7.4

C07K 14/62 (2006.01)

Patent

CA 1038860

ABSTRACT OF THE DISCLOSURE This invention discloses novel human C-peptide derivatives, namely tyrosylated human C-peptide derivatives and radioactive iodinated derivatives. These substances are exceptionally useful for the radioimmunoassay of human C-peptide or proinsulin in serum. The substances are represented by Arg-Arg-Steiner's C-peptide-Lys-Arg which is known as proinsulin 31-65 or C-peptide (35) and includes the two derivatives, tyrosylated C-peptide (35) and the radioiodinated compound thereof. The invention further discloses a method for their synthesis. These derivatives are very useful in immunoassay and the anti- body produced by C-peptide (35) may be diluted up to 10,000 times while still producing useful results.

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