Human proislet peptide, derivatives and analogs thereof, and...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61K 38/22 (2006.01) A61P 5/48 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2609667

Human prolslet Peptides (HIP) and HIP analogs and derivatives thereof, derived from or homologous in sequence to the human REG3A protein, chromosome 2p12, are able to induce islet neogenesis from endogenous pancreatic progenitor cells. Human prolslet Peptides are used either alone or in combination with other pharmaceuticals in the treatment of type 1 and type 2 diabetes and other pathologies related to aberrant glucose, carbohydrate, and/or lipid metabolism, insulin resistance, overweight, obesity, polycystic ovarian syndrome, eating disorders and the metabolic syndrome.

Selon l'invention, des peptides prolslet humains (HIP) et des analogues (HIP) et des dérivés associés, dérivés du chromosome 2p12 de la protéine REG3A humaine ou homologues en séquence audit chromosome sont capables d'induire une néogénèse d'îlot à partir de cellules progénitrices pancréatiques endogènes. Des peptides prolslet humains sont utilisés soit seuls, soit combinés avec d'autres agents pharmaceutiques dans le traitement de diabètes de type 1 et de type 2 et dans d'autres pathologies liées au métabolisme du glucose anormal, des glucides et/ou des lipides, à une résistance à l'insuline, au surpoids, à l'obésité, au syndrome ovarien polykystique, aux troubles alimentaires et au syndrome du métabolisme.

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